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Preventative health care
- Why awareness of zeta potential is important -
Rouleaux formation can be a light transient phenomenon which is usually reversible with grounding for example. However a significant reduction in zeta potential can lead to rouleaux with a sticky formation resistant to breakup. This is extremely important for individuals to know, so that remedial action can be taken - and progress can be monitored. Due to perhaps an underlying pathology, rouleaux formation can become dense over a short period of time, indicating a loss of zeta potential and an increase in blood viscosity, leading to reduced blood flow and various cardiovascular complications. Because tissue perfusion is inversely proportional to blood viscosity, the reduction in zeta potential and the development of rouleaux formation is of great concern and should be addressed as widely as possible. Bi-annual screening of high risk groups to increase awareness and responsibility within the population would be beneficial.
Implication of reduced zeta potential and dense Rouleaux Formation -
Underlying pathology that requires further investigation: Elevated triglycerides can lead to changes in plasma proteins, reduced zeta potential and rouleaux formation, chronic kidney disease can cause changes in plasma proteins, including albumin, leading to rouleaux formation.
Rouleaux formation creates a hyper-coagulable state and may impair oxygen delivery, contributing to tissue ischemia. If the red blood cell aggregation response is indeed systemic, it may have wide reaching multi-systemic effects, including the development or exacerbation of hypertension.
Morbidity is determined by the patient's underlying health status. Ischemic heart disease, diabetes, prethrombotic states, cancer, peripheral vascular disease, retinopathy, and cerebrovascular insufficiency are among the risk factors that will increase the morbidity associated with the reduction in zeta potential and development of rouleaux.
Detection/Screening-
Significant advantage comparison - monitoring rouleaux/zeta potential against monitoring with blood pressure.
The table lists experimental data which needs to be clinically validated
Other than Micro Lab there is no at-home/point-of-care screening for zeta potential/rouleaux currently available.
Because zeta potential has been a time consuming metric to measure in a path lab - it has not been possible to use as a widespread diagnostic tool. Measurement of zeta potential is usually analysed through access to a research pathology lab - Zeta potential analysers such as Electrophoresis and ELS.
Given the association between the reduction in zeta potential and rouleaux formation - with hypertension and cardiovascular risk, a smartphone based blood test such as Micro Lab can be extremely beneficial for a wide range of individuals at risk or with pre-existing conditions.
Facilities that could benefit -
Pharmacies
Healthcare clinics
Doctors surgeries
Hospitals
Care homes
Personal Health Care -
For those interested in personal health and fitness, the red blood cells shape and dynamics indicate changes in vitality, and an increase in zeta potential can be seen during training, and the impact of dietary regimes/supplements and hydration can be monitored for best effect.
Those at risk -
High-risk individuals: Those with a family history of cardiovascular disease, hypertension, diabetes, or kidney disease.
Adults: Individuals typically over 40 years old, zeta potential decreases with age, and those who do not take regular exercise and have a poor diet.
Obese or overweight individuals: Those with a body mass index (BMI) of 30 or higher, as obesity is a significant risk factor for cardiovascular disease.
Individuals at risk of kidney disease or have high triglyceride levels.
Cost saving - CVD Risk assessment - Nation Wide screening for zeta potential
All adults would benefit from an annual zeta potential pin prick screening, but particularly so with 50–60% of adults over 40 in higher risk groups - where a bi-annual test would be more appropriate.
There is the potential to save an astonishing $0.5 trillion annually in the USA alone based on projected figures of reduced incidence of CDV by 50% due to screening and suggesting improved lifestyles to maintain or even improve zeta potential in the population through appropriate protocols. Sunshine, exercise, good food and grounding are all important elements - seaside holidays are good for your health!
The introduction of insurance funded bi-annual zeta potential screening of high risk group of 50M members in the USA would cost around $2 billion based on the cost of infrastructure, with a 250x return on investment. Even with a 1% reduction in disease produces a net saving of $8 billion. This hypothetical example makes a compelling case for zeta potential screening as a cost-effective preventive healthcare strategy.
Market Potential - Health and Fitness -
The global market for home blood testing devices, which includes finger-prick tests used by health and fitness consumers, was estimated at approximately USD $20 billion in 2025. The market is projected to grow at a compound annual growth rate (CAGR) of 10.3% from 2025 to 2035, reaching an estimated USD 53,3 billion by 2035.
With awareness of the importance of zeta potential testing and the ability for competitive athletes to also increase their zeta potential, Micro Lab at an affordable price could be a market leader.
Potential Future Developments -
Artificial intelligence-powered analysis: Leveraging AI to analyse each of the test results and provide personalised recommendations for lifestyle changes and medical interventions.
Telemedicine integration: Enabling remote monitoring and consultation with healthcare professionals to facilitate timely interventions.
Point-of-care testing: Integrating the device at all levels allowing for real-time analysis and decision-making.
Revenue Streams-
Device sales: Revenue generated from the sale of the Micro Lab
Subscription services: Offering subscription-based services for data analysis, personalised recommendations, and telemedicine consultations.
Partnerships and collaborations: Pharmacies, Healthcare providers and insurance companies, to promote the awareness of zeta potential and the benefits of bi-annual screening.
Challenges and Considerations-
Regulatory hurdles: Navigating regulatory approvals and certifications to ensure the device's safe and effective use.
Public awareness and adoption: Educating the public about the device's benefits and encouraging adoption.
Data security and privacy: Ensuring the secure storage and transmission of sensitive health data. The sample slide can be returned to the patient to prevent DNA being harvested without consent.
Reduced Mortality and Morbidity -
The device could lead to a reduction in CVD-related deaths, a saving over time of literally millions of lives.
By preventing or delaying CVD events, individuals could gain years of life, contributing to a healthier and more productive population.
Public Health Benefits -
Increased health literacy: Educating the public about cardiovascular risk factors and the benefits of early detection of low zeta potential could improve health awareness and empower individuals to take control of their health.
Internet examples of high and low zeta potential video blogs could become a thing. Micro fluidics are a fascinating window into human biology.
Reduced healthcare costs: By reducing the number of hospitalisations, complications, and healthcare services required to manage CVD, the device could lead to significant cost savings and improve accessibility.
Reference links to Published articles -
1.https://www.intechopen.com/chapters/72171
Zeta Potential as a Diagnostic Tool to Determine the Angina Risk
2.https://newsi8.com/zeta-potential-what-it-is-and-why-it-matters-to-health/
Zeta Potential, What it Is and Why It Matters to Health
3.https://www.liebertpub.com/doi/10.1089/acm.2011.0820
Earthing (Grounding) the Human Body Reduces Blood Viscosity—a Major Factor in Cardiovascular Disease
Conclusion
Blood pressure monitoring has been the mainstay for early diagnosis and for assessing cardiovascular risk and guiding therapeutic interventions. It is clear zeta potential falls earlier and further than blood pressure rises as a result of rouleaux, highlighting it's potential as an early predictive marker. Not until the advent of Micro Lab has this predictive marker been possible to be usefully employed for regular monitoring of blood health. The underlying causes for reduced zeta potential are complex but it has been shown that grounding, lifestyle and dietary changes have a profound effect on improving zeta potential and blood health, and with appropriate management can help mitigate the adverse effects of rouleaux and increased blood viscosity on cardiovascular health.
Micro Lab
A Pathology Lab in your pocket.
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